| http://purl.uniprot.org/citations/32213161 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32213161 | http://www.w3.org/2000/01/rdf-schema#comment | "The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated the effect of Csx/Nkx2.5 on the expression of cardiac ion channels using P19-derived cardiomyocytes. P19CL6 cells and P19CL6 cells with Csx/Nkx2.5 overexpression (P19CL6-Csx cells) were induced to differentiate into cardiomyocytes by treatment with dimethyl sulfoxide. Action potentials and membrane currents were measured by whole cell patch clamp at different differentiation stage: the early stage (1-5 days after beating had begun) and the late stage (10-15 days after beating). Expression of Csx/Nkx2.5 mRNA was increased as the differentiation stages advanced in both P19CL6 and P19CL6-Csx cells. In action potential configuration, maximal diastolic potentials in P19CL6-Csx cells exhibited more hyperpolarized potential (‒ 64.2 mV) than those in P19CL6 cells (‒ 54.8 mV, p < 0.01) in the early stage. In P19CL6 cells, among 6 different voltage-gated and ligand-operated K+ channels expressed during the early stage, the transient-outward K+ channel was most predominant. By overexpression of Csx/Nkx2.5, developmental decrease in the transient-outward K+ channel was suppressed. Homeobox-containing gene Csx/Nkx2.5 modifies the amount of distinct ionic channels, during differentiation periods, predominantly changing the expression of the transient-outward K+ channel."xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12576-020-00748-z"xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/author | "Ono K."xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/author | "Uchino T."xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/author | "Zheng M.Q."xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/name | "J Physiol Sci"xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/pages | "20"xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/title | "Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward K+ channel expression in pluripotent P19 cell-derived cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/32213161 | http://purl.uniprot.org/core/volume | "70"xsd:string |
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