| http://purl.uniprot.org/citations/32214367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32214367 | http://www.w3.org/2000/01/rdf-schema#comment | "The roles of microRNAs (miRNAs) in liver cancer have attracted much attention in recent years. In this study, we demonstrate that miR-520b is downregulated in MHCC-97H cells, a liver cancer cell line with high potential of metastasis, compared with MHCC-97L cells which has a low potential of metastasis. Furthermore, the enhanced expression of miR-520b could inhibit liver cancer cell migration, while silencing its expression resulted in increased migration. Mixed lineage kinase 3 (MLK3) was identified as a direct and functional new target of miR-520b. This regulation was also confirmed by luciferase reporter assays. In addition, our results showed that overexpression of the MLK3 expression partially reversed the effect of miR-520b on liver cancer cell migration, indicating that MLK3 contributes to the migration in liver cancer. The newly identified miR-520b/MLK3 axis partially elucidates the molecular mechanism of liver cancer cell migration and represents a new potential therapeutic target for liver cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0230716"xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/author | "Wu N."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/author | "Hou G."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/author | "Qian L."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/pages | "e0230716"xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/title | "MLK3 is a newly identified microRNA-520b target that regulates liver cancer cell migration."xsd:string |
| http://purl.uniprot.org/citations/32214367 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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