| http://purl.uniprot.org/citations/32216968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32216968 | http://www.w3.org/2000/01/rdf-schema#comment | "Solitary fibrous tumors are rare mesenchymal tumors derived from soft tissues and vascular walls. NAB2-STAT6 fusion gene serves as a marker gene for this disease and consists of the truncated repressor domain of NGFI-A-Binding protein 2 (NAB2) and the intact activation domain of STAT6. In this study, we found that EGR-1 and the proliferation-related EGR-1 target gene IGF2 were upregulated in NIH-3T3 cells transfected with NAB2-STAT6. Additionally, p-Rb (Ser795) and cyclin D1 levels were upregulated, and cell proliferation was also enhanced. We identified that treatment with the IGF2 inhibitor reduced cell proliferation in NIH-3T3 cells transfected with NAB2-STAT6. The oncogenic progression was enhanced in NIH-3T3 cells transfected with NAB2-STAT6 compared with those transfected with the empty vector. Taken together, our study suggests that the NAB2-STAT6 fusion gene is associated with cell proliferation through EGR-1 transcriptional expression and IGF2 can be a drug target for the treatment of solitary fibrous tumors."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2020.03.090"xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Kim D.S."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Choi S.H."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Park Y.S."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Kim J.Y."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/author | "Ryoo Z.Y."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/pages | "287-292"xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/title | "NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation."xsd:string |
| http://purl.uniprot.org/citations/32216968 | http://purl.uniprot.org/core/volume | "526"xsd:string |
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