| http://purl.uniprot.org/citations/32220331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32220331 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoietic stem cells (HSCs) and skeletal stem cells (SSCs) cohabit in the bone marrow. KITL (C-KIT ligand) from LEPR+ adult bone marrow stromal cells is pivotal for HSC maintenance. In contrast, it remains unclear whether KITL/C-KIT signaling also regulates SSCs. Here, we lineage traced C-KIT+ cells and found that C-KIT was expressed by fetal, but not postnatal skeletal progenitors. Fetal C-KIT+ cells gave rise to 20% of LEPR+ stromal cells in adult bone marrow, forming nearly half of all osteoblasts. Disruption of mTOR signaling in fetal C-KIT+ cells impaired bone formation. Notably, conditional deletion of Kitl from PRX1+ fetal bone marrow stromal cells, but not LEPR+ adult bone marrow stromal cells, significantly increased bone formation. Thus, our work identified C-KIT+ skeletal progenitors as an important source of bones formed during development."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2020.03.001"xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Dong W."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Yin X."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Peng G."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Jing N."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Cui G."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Zhou B.O."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "He D.D."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/author | "Tang X.T."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/pages | "614-630"xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/title | "C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors."xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/32220331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32220331 |
| http://purl.uniprot.org/citations/32220331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32220331 |
| http://purl.uniprot.org/uniprot/#_F7BZW0-mappedCitation-32220331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32220331 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P773-mappedCitation-32220331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32220331 |
| http://purl.uniprot.org/uniprot/#_A9Z1A0-mappedCitation-32220331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32220331 |
| http://purl.uniprot.org/uniprot/#_A4ZVL1-mappedCitation-32220331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32220331 |
| http://purl.uniprot.org/uniprot/#_C7ENW2-mappedCitation-32220331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32220331 |
| http://purl.uniprot.org/uniprot/#_Q63961-mappedCitation-32220331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32220331 |