| http://purl.uniprot.org/citations/32229133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32229133 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt genes encode secreted ligands that play many important roles in the development of metazoans. There are thirteen known Wnt gene subfamilies and seven of these are represented in Drosophila melanogaster. While wingless (wg) is the best understood and most widely studied Wnt gene in Drosophila, the functions of many of the other Drosophila Wnt genes are less well understood. For example, relatively little is known about Wnt6, which is an ancient paralog of wg and they form a conserved Wnt cluster together with Wnt9 (Dwnt4) and Wnt10. Wg and Wnt6 encode similar proteins and exhibit overlapping expression in several tissues during development. Both wg and Wnt6 were previously shown to regulate the development of maxillary palps, important olfactory organs in flies, but it remained unclear how these two ligands may combine to carry out specific functions and how this is regulated. Here, we have further analysed Wnt6 function in the context of maxillary palp development. Surprisingly, we found that Wnt6 does not appear to be necessary for development of maxillary palps. While a deletion of the 5' region of Wnt6 results in very small maxillary palps, we show that this effect is more likely to be a consequence of removing cis-regulatory elements that may regulate wg expression in this tissue rather than through the loss of Wnt6 function. Although, we cannot completely exclude the possibility that Wnt6 may subtly regulate maxillary palp development in combination with wg, our analysis of Wnt6 loss of function mutants suggests this ligand plays a more general role in regulating growth during development. Taken together our results provide new insights into maxillary palp formation and Wnt6 functions in Drosophila, and further evidence for a complex cis-regulatory landscape in the Wnt9-wg-Wnt6-Wnt10 cluster, which may help explain its evolutionary conservation."xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2020.03.012"xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/author | "McGregor A.P."xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/author | "Franke F.A."xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/author | "Mendes C.C."xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/author | "Holzem M."xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/pages | "66-73"xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/title | "Wnt gene regulation and function during maxillary palp development in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://purl.uniprot.org/core/volume | "462"xsd:string |
| http://purl.uniprot.org/citations/32229133 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32229133 |
| http://purl.uniprot.org/citations/32229133 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32229133 |
| http://purl.uniprot.org/uniprot/#_P07548-mappedCitation-32229133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32229133 |
| http://purl.uniprot.org/uniprot/#_P09615-mappedCitation-32229133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32229133 |
| http://purl.uniprot.org/uniprot/#_Q9VM26-mappedCitation-32229133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32229133 |
| http://purl.uniprot.org/uniprot/Q9VM26 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32229133 |
| http://purl.uniprot.org/uniprot/P07548 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32229133 |
| http://purl.uniprot.org/uniprot/P09615 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32229133 |