| http://purl.uniprot.org/citations/32232159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32232159 | http://www.w3.org/2000/01/rdf-schema#comment | "The meiotic prophase I to metaphase I (PI/MI) transition requires chromosome desynapsis and metaphase competence acquisition. However, control of these major meiotic events is poorly understood. Here, we identify an essential role for SKP1, a core subunit of the SKP1-Cullin-F-box (SCF) ubiquitin E3 ligase, in the PI/MI transition. SKP1 localizes to synapsed chromosome axes and evicts HORMAD proteins from these regions in meiotic spermatocytes. SKP1-deficient spermatocytes display premature desynapsis, precocious pachytene exit, loss of PLK1 and BUB1 at centromeres, but persistence of HORMAD, γH2AX, RPA2, and MLH1 in diplonema. Strikingly, SKP1-deficient spermatocytes show sharply reduced MPF activity and fail to enter MI despite treatment with okadaic acid. SKP1-deficient oocytes exhibit desynapsis, chromosome misalignment, and progressive postnatal loss. Therefore, SKP1 maintains synapsis in meiosis of both sexes. Furthermore, our results support a model where SKP1 functions as the long-sought intrinsic metaphase competence factor to orchestrate MI entry during male meiosis."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aaz2129"xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Guan Y."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Luo M."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Schimenti J.C."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Lampson M.A."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Ruthel G."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Wang P.J."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Leu N.A."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Chmatal L."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/author | "Bloom J.C."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/pages | "eaaz2129"xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/title | "SKP1 drives the prophase I to metaphase I transition during male meiosis."xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/32232159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32232159 |
| http://purl.uniprot.org/citations/32232159 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32232159 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDY9-mappedCitation-32232159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32232159 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGA9-mappedCitation-32232159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32232159 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JH14-mappedCitation-32232159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32232159 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUW1-mappedCitation-32232159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32232159 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNM9-mappedCitation-32232159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32232159 |