| http://purl.uniprot.org/citations/32234475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32234475 | http://www.w3.org/2000/01/rdf-schema#comment | "Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control of gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, the loss of dectin-1 on myeloid cells prevents intestinal inflammation, while the lack of mannose receptor (MR) exacerbates it. A marked increase in dectin-1 expression in dextran sulfate sodium (DSS)-exposed MR-deficient mice supports the critical contribution of dectin-1 to colitis outcome. Dectin-1 is crucial for Ly6ChighCCR2high monocyte population enrichment in the blood and their recruitment to inflamed colon as precursors of inflammatory macrophages. Dectin-1 also promotes inflammasome-dependent interleukin-1β (IL-1β) secretion through leukotriene B4 production. Interestingly, colonic inflammation is associated with a concomitant overexpression of dectin-1/CCL2/LTA4H and downregulation of MR on macrophages from IBD patients. Thus, MR and dectin-1 on macrophages are important mucosal inflammatory regulators that contribute to the intestinal inflammation."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.03.018"xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Auwerx J."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Coste A."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Pipy B."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Bertrand B."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Lefevre L."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Meunier E."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Bonnet D."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Prat M."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Jacquemin G."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Aubouy A."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Alric L."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Danjoux M."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Authier H."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Kirzin S."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "AlaEddine M."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Batigne P."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Benmoussa K."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/author | "Rahabi M."xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/pages | "4386-4398.e5"xsd:string |
| http://purl.uniprot.org/citations/32234475 | http://purl.uniprot.org/core/title | "Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response."xsd:string |