| http://purl.uniprot.org/citations/32238803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32238803 | http://www.w3.org/2000/01/rdf-schema#comment | "Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. However, detailed molecular mechanisms of ALK1-mediated signalling remain unclear. Here, we report crystal structures of the BMP10:ALK1 complex at 2.3 Å and the prodomain-bound BMP9:ALK1 complex at 3.3 Å. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence. Introduction of BMP10-specific residues into BMP9 yields BMP10-like ligands with diminished signalling activity in C2C12 cells, validating the tripartite mechanism. The loss of osteogenic signalling in C2C12 does not translate into non-osteogenic activity in vivo and BMP10 also induces bone-formation. Collectively, these data provide insight into ALK1-mediated BMP9 and BMP10 signalling, facilitating therapeutic targeting of this important pathway."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-15425-3"xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Tong Z."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Morrell N.W."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Lawera A."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Salmon R.M."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Grainger D.J."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Reckless J."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Beech J.S."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/author | "Wood J.H."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/pages | "1621"xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/title | "Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms."xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32238803 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32238803 |
| http://purl.uniprot.org/citations/32238803 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32238803 |
| http://purl.uniprot.org/uniprot/#_O95393-mappedCitation-32238803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32238803 |
| http://purl.uniprot.org/uniprot/#_P37023-mappedCitation-32238803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32238803 |
| http://purl.uniprot.org/uniprot/P37023 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32238803 |
| http://purl.uniprot.org/uniprot/O95393 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32238803 |