| http://purl.uniprot.org/citations/32239546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32239546 | http://www.w3.org/2000/01/rdf-schema#comment | "Melatonin (MLT) levels fluctuate according to the external light/dark cycle in both diurnal and nocturnal mammals. We previously demonstrated that melatonin MT2 receptor knockout (MT2 -/- ) mice show a decreased nonrapid eye movement sleep over 24 hours and increased wakefulness during the inactive (light) phase. Here, we investigated the role of MT2 receptors in physiological light/dark cycle fluctuations in the activity of dorsal raphe nucleus (DRN) serotonin (5-HT) neurons and anxiety- and depression-like behavior. We found that the 5-HT burst-firing activity was tonically reduced across the whole 24 hours in MT2 -/- mice compared with MT2 +/+ mice. Importantly, the physiological changes in the spontaneous firing activity of DRN 5-HT neurons during the light/dark cycle were nullified in MT2 -/- mice, with a higher DRN 5-HT neural firing activity during the light phase in MT2 -/- than in MT2 +/+ mice. The role of MT2 receptors over DRN 5-HT neurons was confirmed by acute pharmacological studies in which the selective MT2 receptors agonist UCM1014 dose dependently inhibited DRN 5-HT activity, mostly during the dark phase. Compared with MT2 +/+ , MT2 -/- mice displayed an anxiety-like phenotype in the novelty-suppressed feeding and in the light/dark box tests; while anxiety levels in the light/dark box test were lower during the dark than during the light phase in MT2 +/+ mice, the opposite was seen in MT2 -/- mice. No differences between MT2 +/+ and MT2 -/- mice were observed for depression-like behavior in the forced swim and in the sucrose preference tests. These results suggest that MT2 receptor genetic inactivation impacts 5-HT neurotransmission and interferes with anxiety levels by perturbing the physiologic light/dark pattern."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.org/dc/terms/identifier | "doi:10.1111/jpi.12653"xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/author | "Gobbi G."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/author | "Comai S."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/author | "De Gregorio D."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/author | "Posa L."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/author | "Bedini A."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/author | "Ochoa-Sanchez R."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/name | "J Pineal Res"xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/pages | "e12653"xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/title | "Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MTpisub>2pi/sub> receptors."xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/32239546 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32239546 |
| http://purl.uniprot.org/citations/32239546 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32239546 |
| http://purl.uniprot.org/uniprot/#_P70329-mappedCitation-32239546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32239546 |
| http://purl.uniprot.org/uniprot/#_Q3SXF8-mappedCitation-32239546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32239546 |
| http://purl.uniprot.org/uniprot/#_Q8CIQ6-mappedCitation-32239546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32239546 |
| http://purl.uniprot.org/uniprot/Q8CIQ6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32239546 |
| http://purl.uniprot.org/uniprot/P70329 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32239546 |
| http://purl.uniprot.org/uniprot/Q3SXF8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32239546 |