| http://purl.uniprot.org/citations/32245944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32245944 | http://www.w3.org/2000/01/rdf-schema#comment | "There are thousands of known cellular phosphorylation sites, but the paucity of ways to identify kinases for particular phosphorylation events remains a major roadblock for understanding kinase signaling. To address this, we here develop a generally applicable method that exploits the large number of kinase inhibitors that have been profiled on near-kinome-wide panels of protein kinases. The inhibition profile for each kinase provides a fingerprint that allows identification of unknown kinases acting on target phosphosites in cell extracts. We validate the method on diverse known kinase-phosphosite pairs, including histone kinases, EGFR autophosphorylation, and Integrin β1 phosphorylation by Src-family kinases. We also use our approach to identify the previously unknown kinases responsible for phosphorylation of INCENP at a site within a commonly phosphorylated motif in mitosis (a non-canonical target of Cyclin B-Cdk1), and of BCL9L at S915 (PKA). We show that the method has clear advantages over in silico and genetic screening."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-15428-0"xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Kimura H."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Sako K."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Higgins J.M.G."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Lawless C."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Sen O."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Camara-Donoso M."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Cartwright T.N."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/author | "Watson N.A."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/pages | "1684"xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/title | "Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites."xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32245944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32245944 |
| http://purl.uniprot.org/citations/32245944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32245944 |
| http://purl.uniprot.org/uniprot/#_P00533-mappedCitation-32245944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32245944 |
| http://purl.uniprot.org/uniprot/#_Q86UU0-mappedCitation-32245944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32245944 |
| http://purl.uniprot.org/uniprot/#_Q9NQS7-mappedCitation-32245944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32245944 |
| http://purl.uniprot.org/uniprot/Q9NQS7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32245944 |
| http://purl.uniprot.org/uniprot/P00533 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32245944 |
| http://purl.uniprot.org/uniprot/Q86UU0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32245944 |