| http://purl.uniprot.org/citations/32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32249787 | http://www.w3.org/2000/01/rdf-schema#comment | "Rod photoreceptor synapses use large, ribbon-type active zones for continuous synaptic transmission during light and dark. Since ribbons are physically connected to the active zones, we asked whether illumination-dependent changes of ribbons influence Cav1.4/RIM2 protein clusters at the active zone and whether these illumination-dependent effects at the active zone require the presence of the synaptic ribbon. We found that synaptic ribbon length and the length of presynaptic Cav1.4/RIM2 clusters are tightly correlated. Dark-adaptation did not change the number of ribbons and active zone puncta. However, mean ribbon length and length of presynaptic Cav1.4/RIM2 clusters increased significantly during dark-adaptation when tonic exocytosis is highest. In the present study, we identified by the analyses of synaptic ribbon-deficient RIBEYE knockout mice that synaptic ribbons are (1) needed to stabilize Cav1.4/RIM2 at rod photoreceptor active zones and (2) are required for the darkness-induced active zone enrichment of Cav1.4/RIM2. These data propose a role of the ribbon in active zone stabilization and suggest a homeostatic function of the ribbon in illumination-dependent active zone remodeling."xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-62734-0"xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/author | "Maxeiner S."xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/author | "Schmitz F."xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/author | "Dembla M."xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/author | "Dembla E."xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/pages | "5957"xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/title | "Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses."xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/32249787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32249787 |
| http://purl.uniprot.org/citations/32249787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32249787 |
| http://purl.uniprot.org/uniprot/#_E9QA96-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_E9PZG2-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_E9Q0T4-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_E9Q0V8-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_E9Q123-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_P56546-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_A0A338P6V5-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_B1AVA4-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_B1AVA5-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_B1AVA6-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |
| http://purl.uniprot.org/uniprot/#_E9Q815-mappedCitation-32249787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32249787 |