| http://purl.uniprot.org/citations/32251290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32251290 | http://www.w3.org/2000/01/rdf-schema#comment | "Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight loss; however, the underlying molecular mechanism remains elusive. Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a critical component of a SNS/brown adipose tissue (BAT)/thermogenesis axis. LepR neuron-specific deletion of Sh2b1 abrogates leptin-stimulated sympathetic nerve activation and impairs BAT thermogenic programs, leading to reduced core body temperature and cold intolerance. The adipose SNS degenerates progressively in mutant mice after 8 weeks of age. Adult-onset ablation of Sh2b1 in the mediobasal hypothalamus also impairs the SNS/BAT/thermogenesis axis; conversely, hypothalamic overexpression of human SH2B1 has the opposite effects. Mice with either LepR neuron-specific or adult-onset, hypothalamus-specific ablation of Sh2b1 develop obesity, insulin resistance, and liver steatosis. In contrast, hypothalamic overexpression of SH2B1 protects against high fat diet-induced obesity and metabolic syndromes. Our results unravel an unrecognized LepR neuron Sh2b1/SNS/BAT/thermogenesis axis that combats obesity and metabolic disease."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-15328-3"xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Su H."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Kim M.H."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Rui L."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Myers M.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/author | "Owyang C."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/pages | "1517"xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/title | "Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease."xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32251290 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32251290 |
| http://purl.uniprot.org/citations/32251290 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32251290 |
| http://purl.uniprot.org/uniprot/#_D0FZQ3-mappedCitation-32251290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251290 |
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| http://purl.uniprot.org/uniprot/#_A2AV66-mappedCitation-32251290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251290 |
| http://purl.uniprot.org/uniprot/#_B4DQ00-mappedCitation-32251290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251290 |
| http://purl.uniprot.org/uniprot/#_B4DLN5-mappedCitation-32251290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251290 |