| http://purl.uniprot.org/citations/32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32251420 | http://www.w3.org/2000/01/rdf-schema#comment | "The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5), sense cytoplasmic viral RNA and initiate innate antiviral responses. How RIG-I and MDA5 are differentially regulated remains enigmatic. In this study, we identified the guanylate-binding protein (GBP) and zinc-finger FYVE domain-containing protein ZFYVE1 as a negative regulator of MDA5-but not RIG-I-mediated innate antiviral responses. ZFYVE1-deficiency promoted MDA5-but not RIG-I-mediated transcription of downstream antiviral genes. Comparing to wild-type mice, Zfyve1-/-mice were significantly protected from lethality induced by encephalomyocarditis virus (EMCV) that is sensed by MDA5, whereas Zfyve1-/- and Zfyve1+/+ mice were comparable to death induced by vesicular stomatitis virus (VSV) that is sensed by RIG-I. Mechanistically, ZFYVE1 interacted with MDA5 but not RIG-I. ZFYVE1 bound to viral RNA and decreased the ligand binding and oligomerization of MDA5. These findings suggest that ZFYVE1 acts as a specific negative regulator of MDA5-mediated innate immune responses by inhibiting its ligand binding and oligomerization."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1008457"xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/author | "Zang R."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/author | "Shu H.B."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/author | "Lei C.Q."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/pages | "e1008457"xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/title | "ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response."xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/32251420 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32251420 |
| http://purl.uniprot.org/citations/32251420 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32251420 |
| http://purl.uniprot.org/uniprot/#_A1L0V6-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_A7YY79-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VKG0-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_A2AP29-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_D2CGM4-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_D2CGM5-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_Q05CC6-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_Q3U0Y5-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |
| http://purl.uniprot.org/uniprot/#_Q3UT32-mappedCitation-32251420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32251420 |