| http://purl.uniprot.org/citations/32255763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32255763 | http://www.w3.org/2000/01/rdf-schema#comment | "BK channels are expressed in intercalated cells (ICs) and principal cells (PCs) in the cortical collecting duct (CCD) of the mammalian kidney and have been proposed to be responsible for flow-induced K+ secretion (FIKS) and K+ adaptation. To examine the IC-specific role of BK channels, we generated a mouse with targeted disruption of the pore-forming BK α subunit (BKα) in ICs (IC-BKα-KO). Whole cell charybdotoxin-sensitive (ChTX-sensitive) K+ currents were readily detected in control ICs but largely absent in ICs of IC-BKα-KO mice. When placed on a high K+ (HK) diet for 13 days, blood [K+] was significantly greater in IC-BKα-KO mice versus controls in males only, although urinary K+ excretion rates following isotonic volume expansion were similar in males and females. FIKS was present in microperfused CCDs isolated from controls but was absent in IC-BKα-KO CCDs of both sexes. Also, flow-stimulated epithelial Na+ channel-mediated (ENaC-mediated) Na+ absorption was greater in CCDs from female IC-BKα-KO mice than in CCDs from males. Our results confirm a critical role of IC BK channels in FIKS. Sex contributes to the capacity for adaptation to a HK diet in IC-BKα-KO mice."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.130553"xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Sheng S."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Wu P."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Kohan D.E."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Flores D."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Kleyman T.R."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Mutchler S.M."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Jackson E.K."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Carrisoza-Gaytan R."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Satlin L.M."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Nkashama L.J."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Subramanya A.R."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Marciszyn A.L."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Heja S."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/author | "Ray E.C."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/pages | "130553"xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/title | "Intercalated cell BKalpha subunit is required for flow-induced K+ secretion."xsd:string |
| http://purl.uniprot.org/citations/32255763 | http://purl.uniprot.org/core/volume | "5"xsd:string |