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| http://purl.uniprot.org/citations/32260198 | http://www.w3.org/2000/01/rdf-schema#comment | "In a recent report, no significance of transglutaminase 2 (TGase 2) was noted in the analyses of expression differences between normal and clear cell renal cell carcinoma (ccRCC), although we found that knock down of TGase 2 induced significant p53-mediated cell death in ccRCC. Generally, to find effective therapeutic targets, we need to identify targets that belong specifically to a cancer phenotype that can be differentiated from a normal phenotype. Here, we offer precise reasons why TGase 2 may be the first therapeutic target for ccRCC, according to several lines of evidence. TGase 2 is negatively regulated by von Hippel-Lindau tumor suppressor protein (pVHL) and positively regulated by hypoxia-inducible factor 1-α (HIF-1α in renal cell carcinoma (RCC). Therefore, most of ccRCC presents high level expression of TGase 2 because over 90% of ccRCC showed VHL inactivity through mutation and methylation. Cell death, angiogenesis and drug resistance were specifically regulated by TGase 2 through p53 depletion in ccRCC because over 90% of ccRCC express wild type p53, which is a cell death inducer as well as a HIF-1α suppressor. Although there have been no detailed studies of the physiological role of TGase 2 in multi-omics analyses of ccRCC, a life-long study of the physiological roles of TGase 2 led to the discovery of the first target as well as the first therapeutic treatment for ccRCC in the clinical field."xsd:string |
| http://purl.uniprot.org/citations/32260198 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms21072493"xsd:string |
| http://purl.uniprot.org/citations/32260198 | http://purl.uniprot.org/core/author | "Kim S.Y."xsd:string |
| http://purl.uniprot.org/citations/32260198 | http://purl.uniprot.org/core/author | "Keillor J.W."xsd:string |
| http://purl.uniprot.org/citations/32260198 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32260198 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/32260198 | http://purl.uniprot.org/core/pages | "E2493"xsd:string |
| http://purl.uniprot.org/citations/32260198 | http://purl.uniprot.org/core/title | "A Precision Strategy to Cure Renal Cell Carcinoma by Targeting Transglutaminase 2."xsd:string |
| http://purl.uniprot.org/citations/32260198 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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