| http://purl.uniprot.org/citations/32265276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32265276 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyubiquitin chains linked via lysine (K) 63 play an important role in endocytosis and membrane trafficking. Their primary source is the ubiquitin protein ligase (E3) Rsp5/NEDD4, which acts as a key regulator of membrane protein sorting. The heterodimeric ubiquitin-conjugating enzyme (E2), Ubc13-Mms2, catalyses K63-specific polyubiquitylation in genome maintenance and inflammatory signalling. In budding yeast, the only E3 proteins known to cooperate with Ubc13-Mms2 so far is a nuclear RING finger protein, Rad5, involved in the replication of damaged DNA. Here, we report a contribution of Ubc13-Mms2 to the sorting of membrane proteins to the yeast vacuole via the multivesicular body (MVB) pathway. In this context, Ubc13-Mms2 cooperates with Pib1, a FYVE-RING finger protein associated with internal membranes. Moreover, we identified a family of membrane-associated FYVE-(type)-RING finger proteins as cognate E3 proteins for Ubc13-Mms2 in several species, and genetic analysis indicates that the contribution of Ubc13-Mms2 to membrane trafficking in budding yeast goes beyond its cooperation with Pib1. Thus, our results widely implicate Ubc13-Mms2 as an Rsp5-independent source of K63-linked polyubiquitin chains in the regulation of membrane protein sorting.This article has an associated First Person interview with the first author of the paper."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.244566"xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Khmelinskii A."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Leon S."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Jacobs S.C."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Santt O."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Ulrich H.D."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Albert T.K."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Albanese V."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Renz C."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/author | "Troster V."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/pages | "jcs244566"xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/title | "Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting."xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/32265276 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32265276 |
| http://purl.uniprot.org/citations/32265276 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32265276 |
| http://purl.uniprot.org/uniprot/P53152#attribution-62FAFD60FCE6916262B3EE26B07D8408 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32265276 |
| http://purl.uniprot.org/uniprot/P53152#attribution-DC7E9139C57F6D243EBA9D329C9D859B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32265276 |
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| http://purl.uniprot.org/uniprot/P52490#attribution-DC7E9139C57F6D243EBA9D329C9D859B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32265276 |
| http://purl.uniprot.org/uniprot/#_A0M8W4-mappedCitation-32265276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32265276 |
| http://purl.uniprot.org/uniprot/#_G3V113-mappedCitation-32265276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32265276 |