| http://purl.uniprot.org/citations/32267063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32267063 | http://www.w3.org/2000/01/rdf-schema#comment | "All trophoblast subtypes of the placenta are derived from trophoblast stem cells (TSCs). TSCs have the capacity to self-renew, but how the proliferation of these cells is regulated in the undifferentiated state has been largely unclear. We now show that the F-box protein Skp2 regulates the proliferation of TSCs and thereby plays a pivotal role in placental development in mice on the C57BL/6 background. The placenta of Skp2-/- mouse embryos on the C57BL/6 background was smaller than that of their Skp2+/+ littermates, with the mutant embryos also manifesting intrauterine growth retardation. Although the Skp2-/- mice were born alive, most of them died before postnatal day 21, presumably as a result of placental defects. Depletion of Skp2 in TSCs cultured in the undifferentiated state resulted in a reduced rate of proliferation and arrest of the cell cycle in G1 phase, indicative of a defect in self-renewal capacity. The cell cycle arrest apparent in Skp2-deficient TSCs was reversed by additional ablation of the cyclin-dependent kinase inhibitor (CKI) p57 but not by that of the CKI p27. Our results thus suggest that Skp2-mediated degradation of p57 is an important determinant of the self-renewal capacity of TSCs during placental development, at least in mice of certain genetic backgrounds."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.org/dc/terms/identifier | "doi:10.1111/gtc.12769"xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/author | "Nishiyama M."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/author | "Yamauchi Y."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/author | "Muto Y."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/author | "Nakayama K.I."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/author | "Nakatsumi H."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/author | "Nita A."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/pages | "427-438"xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/title | "Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development."xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/32267063 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32267063 |
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