| http://purl.uniprot.org/citations/32267915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32267915 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor β (TGFβ) is a crucial factor in fibrosis, and transcriptional intermediary factor 1γ (TIF1γ) is a negative regulator of the TGFβ pathway; however, its role in liver fibrosis is unknown. In this study, mesenchymal stem cells derived from human embryonic stem cells (hE-MSCs) that secrete hepatocyte growth factor (HGF) were used to observe the repair of thioacetamide (TAA)-induced liver fibrosis. Our results showed that TIF1γ was significantly decreased in LX2 cells when exposed to TGFβ1. Such decrease of TIF1γ was significantly prevented by co-culture with hE-MSCs. Interaction of TIF1γ with SMAD2/3 and binding to the promoter of the α-smooth muscle gene (αSMA) suppressed αSMA expression. Phosphorylation of cAMP response element-binding protein (CREB) and binding on the TIF1γ promoter region induced TIF1γ expression. Furthermore, hepatic stellate cell-specific TIF1γ-knockout mice showed aggravation of liver fibrosis. In conclusion, loss of TIF1γ aggravates fibrosis, suggesting that a strategy to maintain TIF1γ during liver injury would be a promising therapeutic approach to prevent or reverse liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20190402"xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Lee S.Y."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Hwang I."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Lee E.J."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Park H."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Kim I."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Kim K.C."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Park J.N."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Moon D."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Kim H.S.'"xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/author | "Jun D.W."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/pages | "e20190402"xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/title | "Hepatic stellate cell-specific knockout of transcriptional intermediary factor 1gamma aggravates liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/32267915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32267915 |
| http://purl.uniprot.org/citations/32267915 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32267915 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE09-mappedCitation-32267915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32267915 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGY5-mappedCitation-32267915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32267915 |