| http://purl.uniprot.org/citations/32268092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32268092 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone 3 gene mutations are the eponymous drivers in diffuse midline gliomas (DMGs), aggressive pediatric brain cancers for which no curative therapy currently exists. These recurrent oncohistones induce a global loss of repressive H3K27me3 residues and broad epigenetic dysregulation. In order to identify therapeutically targetable dependencies within this disease context, we performed an RNAi screen targeting epigenetic/chromatin-associated genes in patient-derived DMG cultures. This identified AFF4, the scaffold protein of the super elongation complex (SEC), as a molecular dependency in DMG. Interrogation of SEC function demonstrates a key role for maintaining clonogenic potential while promoting self-renewal of tumor stem cells. Small-molecule inhibition of SEC using clinically relevant CDK9 inhibitors restores regulatory RNA polymerase II pausing, promotes cellular differentiation, and leads to potent anti-tumor effect both in vitro and in patient-derived xenograft models. These studies present a rationale for further exploration of SEC inhibition as a promising therapeutic approach to this intractable disease."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.03.049"xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Venkataraman S."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Fosmire S."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Madhavan K."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Green A.L."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Pierce A."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Danis E."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Vibhakar R."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Serkova N.J."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Balakrishnan I."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Walker F.M."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Foreman N.K."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Dahl N.A."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/author | "Gilani A."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/pages | "107485"xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/title | "Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma."xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/32268092 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32268092 |
| http://purl.uniprot.org/citations/32268092 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32268092 |
| http://purl.uniprot.org/uniprot/#_Q8TAX5-mappedCitation-32268092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32268092 |