| http://purl.uniprot.org/citations/32268096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32268096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32268096 | http://www.w3.org/2000/01/rdf-schema#comment | "In higher eukaryotes, the mRNA sequence in the direct vicinity of the start codon, called the Kozak sequence (CRCCaugG, where R is a purine), is known to influence the rate of the initiation process. However, the molecular basis underlying its role remains poorly understood. Here, we present the cryoelectron microscopy (cryo-EM) structures of mammalian late-stage 48S initiation complexes (LS48S ICs) in the presence of two different native mRNA sequences, β-globin and histone 4, at overall resolution of 3 and 3.5 Å, respectively. Our high-resolution structures unravel key interactions from the mRNA to eukaryotic initiation factors (eIFs): 1A, 2, 3, 18S rRNA, and several 40S ribosomal proteins. In addition, we are able to study the structural role of ABCE1 in the formation of native 48S ICs. Our results reveal a comprehensive map of ribosome/eIF-mRNA and ribosome/eIF-tRNA interactions and suggest the impact of mRNA sequence on the structure of the LS48S IC."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.03.061"xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.03.061"xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Kuhn L."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Kuhn L."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Hashem Y."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Hashem Y."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Bochler A."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Bochler A."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Simonetti A."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Simonetti A."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Guca E."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/author | "Guca E."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/pages | "107497"xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/pages | "107497"xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/title | "Structural Insights into the Mammalian Late-Stage Initiation Complexes."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/title | "Structural Insights into the Mammalian Late-Stage Initiation Complexes."xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/32268096 | http://purl.uniprot.org/core/volume | "31"xsd:string |