| http://purl.uniprot.org/citations/32273477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32273477 | http://www.w3.org/2000/01/rdf-schema#comment | "Mantle cell lymphoma (MCL) with MYC rearrangement (MYC-R) is rare and little is known about the importance of MYC extra copies (EC) in the absence of MYC-R in MCL patients. This study includes 88 MCL patients with MYC tested by fluorescence in situ hybridization and/or conventional cytogenetics, including 27 with MYC-R, 21 with MYC-EC, and 40 with normal (NL) MYC. MCL patients with MYC-R more often had blastoid/pleomorphic morphology; a higher frequency of CD10, MYC, and simultaneous MYC and BCL2 expression; a higher level of MYC; and a higher Ki67 proliferation rate (p<0.05) than those without MYC-R. Although patients with MYC-R more frequently received aggressive chemotherapy (p=0.001), their overall survival (OS) was significantly shorter than those without MYC-R. Compared with patients with MYC/BCL2 double hit lymphoma (DHL), patients with MYC-R MCL had a similar OS but more commonly had bone marrow involvement, stage 4 disease, and a different immunophenotype. MCL patients with MYC-EC showed an OS intermediate between those with MYC-R and MYC-NL, either all or only blastoid/pleomorphic MCL patients included. Multivariate analysis showed that MYC-R, but not MYC-EC, had an independent and negative impact on OS. In conclusion, MYC-R but not MYC-EC showed a higher MYC expression and is an adverse prognostic factor for MCL patients. Although the OS of MCL patients with MYC-R is similar to that of MYC/BCL2 DHL patients, these groups have different clinicopathologic features supporting the retention of MCL with MYC-R in the category of MCL, as recommended in the revised World Health Organization classification."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.org/dc/terms/identifier | "doi:10.3324/haematol.2019.243071"xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Tang G."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Jain P."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Lin P."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Yin C.C."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/author | "Medeiros L.J."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/name | "Haematologica"xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/pages | "1381-1389"xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/title | "MYC rearrangement but not extra MYC copies is an independent prognostic factor in patients with mantle cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/32273477 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32273477 |
| http://purl.uniprot.org/citations/32273477 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32273477 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-32273477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32273477 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-32273477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32273477 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-32273477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32273477 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-32273477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32273477 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-32273477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32273477 |