| http://purl.uniprot.org/citations/32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32277031 | http://www.w3.org/2000/01/rdf-schema#comment | "In all animals, the intestinal epithelium forms a tight barrier to the environment. The epithelium regulates the absorption of nutrients, mounts immune responses, and prevents systemic infections. Here, we investigate the consequences of tumorigenesis on the microbiome using a Drosophila intestinal tumor model. We show that upon loss of BMP signaling, tumors lead to aberrant activation of JNK/Mmp2 signaling, followed by intestinal barrier dysfunction and commensal imbalance. In turn, the dysbiotic microbiome triggers a regenerative response and stimulates tumor growth. We find that inhibiting JNK signaling or depletion of the microbiome restores barrier function of the intestinal epithelium, leading to a reestablishment of host-microbe homeostasis, and organismic lifespan extension. Our experiments identify a JNK-dependent feedback amplification loop between intestinal tumors and the microbiome. They also highlight the importance of controlling the activity level of JNK signaling to maintain epithelial barrier function and host-microbe homeostasis."xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1913976117"xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://purl.uniprot.org/core/author | "Boutros M."xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32277031 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://purl.uniprot.org/core/pages | "9401-9412"xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://purl.uniprot.org/core/title | "JNK-dependent intestinal barrier failure disrupts host-microbe homeostasis during tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/32277031 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32277031 |
| http://purl.uniprot.org/citations/32277031 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFC0-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHU8-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHX7-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JDA7-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCU7-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD53-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7H5-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A1Z8F4-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EEQ6-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EF36-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_A8MPH9-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |
| http://purl.uniprot.org/uniprot/#_C0HK98-mappedCitation-32277031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32277031 |