| http://purl.uniprot.org/citations/32293069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32293069 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute renal depletion of sorting nexin 1 (SNX1) in mice results in blunted natriuretic response and hypertension due to impaired dopamine D5 receptor (D5 R) activity. We elucidated the molecular mechanisms for these phenotypes in Snx1-/- mice. These mice had increased renal expressions of angiotensin II type 1 receptor (AT1 R), NADPH oxidase (NOX) subunits, D5 R, and NaCl cotransporter. Basal reactive oxygen species (ROS), NOX activity, and blood pressure (BP) were also higher in Snx1-/- mice, which were normalized by apocynin, a drug that prevents NOX assembly. Renal proximal tubule (RPT) cells from hypertensive (HT) Euro-American males had deficient SNX1 activity, impaired D5 R endocytosis, and increased ROS compared with cells from normotensive (NT) Euro-American males. siRNA-mediated depletion of SNX1 in RPT cells from NT subjects led to a blunting of D5 R agonist-induced increase in cAMP production and decrease in Na+ transport, effects that were normalized by over-expression of SNX1. Among HT African-Americans, three of the 12 single nucleotide polymorphisms interrogated for the SNX1 gene were associated with a decrease in systolic BP in response to hydrochlorothiazide (HCTZ). The results illustrate a new paradigm for the development of hypertension and imply that the trafficking protein SNX1 may be a crucial determinant for hypertension and response to antihypertensive therapy."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.201902448r"xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Zeng C."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Jones J.E."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Jose P.A."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Johnson J.A."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Boerwinkle E."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Armando I."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Weinman E.J."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Turner S.T."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Felder R.A."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Villar V.A.M."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Chapman A.B."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Asico L.D."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Schwartz G.L."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Beitelshees A.L."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Cooper-DeHoff R.M."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Gums J.G."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Feranil J.B."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/author | "Cuevas S.G."xsd:string |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32293069 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |