| http://purl.uniprot.org/citations/32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32296392 | http://www.w3.org/2000/01/rdf-schema#comment | "Gestational diabetes mellitus (GDM) is a disease that changes the function of microvascular of placenta. MicroRNA (miRNA) expression in placenta may contribute to the pathogenesis of GDM. Here, we evaluate the role and function of miR-29b in the development of GDM. This study discovered that miR-29b expression was lower in placentas derived from patients with GDM than that in control placentas. MiR-29b over-expression inhibited cell growth and migration, and miR-29b knockdown promoted cell migration. Then we predicted and confirmed that HIF3A was a direct target of miR-29b with two specific binding sites at the recognition sequences of miR-29b in 3'-UTR of HIF3A mRNA, which was negatively correlated with miR-29b expression level. The up-regulation of HIF3A partially antagonized the inhibitory effect of miR-29b over-expression on cell growth and migration. The enhancement of cell migration induced by miR-29b knockdown was attenuated by down-regulating HIF3A. These results imply that down-regulation of miR-29b may be related with the development of GDM partially via increasing the expression of HIF3A, which may provide a new insight for the mechanism of GDM."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.org/dc/terms/identifier | "doi:10.3389/fendo.2020.00169"xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/author | "Tian S."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/author | "Guan C.Y."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/author | "Xia H.F."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/author | "Sun D.G."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/name | "Front Endocrinol (Lausanne)"xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/pages | "169"xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/title | "The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism."xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32296392 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32296392 |
| http://purl.uniprot.org/citations/32296392 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32296392 |
| http://purl.uniprot.org/uniprot/#_B2RBI6-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |
| http://purl.uniprot.org/uniprot/#_B4DSD9-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |
| http://purl.uniprot.org/uniprot/#_B4E3J3-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |
| http://purl.uniprot.org/uniprot/#_O95262-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |
| http://purl.uniprot.org/uniprot/#_H0YDZ5-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |
| http://purl.uniprot.org/uniprot/#_M0R104-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |
| http://purl.uniprot.org/uniprot/#_Q9UPH7-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |
| http://purl.uniprot.org/uniprot/#_Q9HAM5-mappedCitation-32296392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32296392 |