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http://purl.uniprot.org/citations/32297641http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32297641http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The purpose of this study was to explore the prognostic role of c-MYC amplification in colorectal cancer, particularly in schistosomiasis-associated colorectal cancer.

Methods

Three hundred and fifty four cases of colorectal cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, were retrospectively analyzed in a tissue microarray (TMA) format, with fluorescence in situ hybridization (FISH) assay and immunohistochemistry (IHC).

Results

c-MYC gene amplification was found in 14.1% (50 out of 354) of patients with colorectal cancer and was correlated with old age (P = 0.028), positive lymph node metastasis (P = 0.004) and advanced stage tumors (P = 0.002). The overexpression of c-MYC was closely associated with the amplification status (P = 0.023). Kaplan-Meier survival curves for overall survival (OS) showed a statistically significant difference for patients with c-MYC amplification in full cohort of colorectal cancer, stage III-IV set and patients with lymph node metastasis (P = 0.002, 0.034, 0.012, respectively). Further analysis found c-MYC amplification associated with poorer survival in the subgroup of colorectal cancer with schistosomiasis (CRC-S, P < 0.001), but not in colorectal cancer without schistosomiasis (CRC-NS, P = 0.155). By multivariate analysis, c-MYC amplification was an independent poor-prognostic factor in CRC-S set (P = 0.046).

Conclusions

Our study firstly found c-MYC amplification could predict poor prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal cancer without schistosomiasis."xsd:string
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http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Bu D."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Hou Y."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Huang S."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Huang J."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Liu J."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Jing H."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Pan W."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Wang W."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Jiang D."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Yao J."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/author"Lu K."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/name"Jpn J Clin Oncol"xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/pages"446-455"xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/title"The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer."xsd:string
http://purl.uniprot.org/citations/32297641http://purl.uniprot.org/core/volume"50"xsd:string
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