| http://purl.uniprot.org/citations/32299921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32299921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32299921 | http://www.w3.org/2000/01/rdf-schema#comment | "Control of messenger RNA (mRNA) decay rate is intimately connected to translation elongation, but the spatial coordination of these events is poorly understood. The Ccr4-Not complex initiates mRNA decay through deadenylation and activation of decapping. We used a combination of cryo-electron microscopy, ribosome profiling, and mRNA stability assays to examine the recruitment of Ccr4-Not to the ribosome via specific interaction of the Not5 subunit with the ribosomal E-site in Saccharomyces cerevisiae This interaction occurred when the ribosome lacked accommodated A-site transfer RNA, indicative of low codon optimality. Loss of the interaction resulted in the inability of the mRNA degradation machinery to sense codon optimality. Our findings elucidate a physical link between the Ccr4-Not complex and the ribosome and provide mechanistic insight into the coupling of decoding efficiency with mRNA stability."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aay6912"xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aay6912"xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Inada T."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Inada T."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Sugiyama T."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Sugiyama T."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Matsuo Y."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Matsuo Y."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Buschauer R."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Buschauer R."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Becker T."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Becker T."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Coller J."xsd:string |
| http://purl.uniprot.org/citations/32299921 | http://purl.uniprot.org/core/author | "Coller J."xsd:string |