| http://purl.uniprot.org/citations/32302557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32302557 | http://www.w3.org/2000/01/rdf-schema#comment | "Adult hippocampal neurogenesis is strongly dependent on thyroid hormone (TH). Whether TH signaling regulates this process in a cell-autonomous or non-autonomous manner remains unknown. To answer this question, we used global and conditional knockouts of the TH transporter monocarboxylate transporter 8 (MCT8), having first used FACS and immunohistochemistry to demonstrate that MCT8 is the only TH transporter expressed on neuroblasts and adult slice cultures to confirm a necessary role for MCT8 in neurogenesis. Both mice with a global deletion or an adult neural stem cell-specific deletion of MCT8 showed decreased expression of the cell-cycle inhibitor P27KIP1, reduced differentiation of neuroblasts, and impaired generation of new granule cell neurons, with global knockout mice also showing enhanced neuroblast proliferation. Together, our results reveal a cell-autonomous role for TH signaling in adult hippocampal neurogenesis alongside non-cell-autonomous effects on cell proliferation earlier in the lineage."xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2020.03.014"xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/author | "Heuer H."xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/author | "Mayerl S."xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/author | "Ffrench-Constant C."xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/pages | "845-860"xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/title | "Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling."xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/32302557 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32302557 |
| http://purl.uniprot.org/citations/32302557 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32302557 |
| http://purl.uniprot.org/uniprot/#_Q05BA2-mappedCitation-32302557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32302557 |
| http://purl.uniprot.org/uniprot/#_O70324-mappedCitation-32302557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32302557 |
| http://purl.uniprot.org/uniprot/#_Q8K3S7-mappedCitation-32302557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32302557 |
| http://purl.uniprot.org/uniprot/O70324 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32302557 |
| http://purl.uniprot.org/uniprot/Q05BA2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32302557 |
| http://purl.uniprot.org/uniprot/Q8K3S7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32302557 |