DESCRIBE <http://purl.uniprot.org/citations/32303780>

Subject	Predicate	Object
http://purl.uniprot.org/citations/32303780	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32303780	http://www.w3.org/2000/01/rdf-schema#comment	" Objective and design CHRFAM7A is a unique human gene that encodes a dominant negative inhibitor of the α7 nicotinic acetylcholine receptor. We have recently shown that CHRFAM7A is expressed in human leukocytes, increases cel-cell adhesion, and regulates the expression of genes associated with leukocyte migration. Material Human THP-1, RAW264.7 and HEK293 cells. Methods Cell migration, cell proliferation and colony formation in soft agar to compare the biological activity of vector vs. CHRFAM7A-transduced cells. Results We show that gene delivery of CHRFAM7A into the THP-1 human monocytic cell line reduces cell migration, reduces chemotaxis to monocyte chemoattractant protein, and reduces colony formation in soft agar. Conclusion Taken together, the findings demonstrate that CHRFAM7A regulates the biological activity of monocytes/macrophages to migrate and undergo anchorage-independent growth in vitro."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.org/dc/terms/identifier	"doi:10.1007/s00011-020-01349-7"xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/author	"Cohen O."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/author	"Baird A."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/author	"Eliceiri B.P."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/author	"Chan T.W."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/author	"Costantini T.W."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/author	"Langness S."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/date	"2020"xsd:gYear
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/name	"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/pages	"631-633"xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/title	"CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro."xsd:string
http://purl.uniprot.org/citations/32303780	http://purl.uniprot.org/core/volume	"69"xsd:string
http://purl.uniprot.org/citations/32303780	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/32303780
http://purl.uniprot.org/citations/32303780	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/32303780
http://purl.uniprot.org/uniprot/#_A0A0A6YYA8-mappedCitation-32303780	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/32303780
http://purl.uniprot.org/uniprot/#_Q494W8-mappedCitation-32303780	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/32303780
http://purl.uniprot.org/uniprot/#_P36544-mappedCitation-32303780	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/32303780
http://purl.uniprot.org/uniprot/P36544	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/32303780
http://purl.uniprot.org/uniprot/A0A0A6YYA8	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/32303780
http://purl.uniprot.org/uniprot/Q494W8	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/32303780