| http://purl.uniprot.org/citations/32304628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32304628 | http://www.w3.org/2000/01/rdf-schema#comment | "Depression is a common disorder that affects women at twice the rate of men. Here, we report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts, represent about one-third of the differentially expressed genes in the brains of depressed humans and display complex region- and sex-specific patterns of regulation. We identified the primate-specific, neuronal-enriched gene LINC00473 as downregulated in prefrontal cortex (PFC) of depressed females but not males. Using viral-mediated gene transfer to express LINC00473 in adult mouse PFC neurons, we mirrored the human sex-specific phenotype by inducing stress resilience solely in female mice. This sex-specific phenotype was accompanied by changes in synaptic function and gene expression selectively in female mice and, along with studies of human neuron-like cells in culture, implicates LINC00473 as a CREB effector. Together, our studies identify LINC00473 as a female-specific driver of stress resilience that is aberrant in female depression."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2020.03.023"xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Tan C."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Nestler E.J."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Loh Y.E."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Tamminga C.A."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Calipari E.S."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Ramakrishnan A."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Walker D.M."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Brennand K.J."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Labonte B."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Duffy J.E."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Issler O."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Hamilton P.J."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Hartley B.J."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Parise E.M."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Torres-Berrio A."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Pena C.J."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Purushothaman I."xsd:string |
| http://purl.uniprot.org/citations/32304628 | http://purl.uniprot.org/core/author | "Lorsch Z.S."xsd:string |