| http://purl.uniprot.org/citations/32312148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32312148 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular uptake of clinically important deoxynucleoside analogs is mediated by nucleoside transporters including the human equilibrative nucleoside transporter 1 (hENT1) and the concentrative nucleoside transporter-1 (hCNT1). These transporters are responsible for influx of cytarabine and reduced hENT1 expression is a major resistance mechanism in acute myeloid leukemia. We determined hENT1 and hCNT1 protein expression by immunocytochemistry in 50 diagnostic pediatric acute myeloid leukemia patient samples. All samples expressed hENT1 [9/43 (21%) low; 26/43 (60%) medium and 8/43 (19%) high] and hCNT1 [2/42 (5%) low; 35/42 (83%) medium and 5/42 (12%) high] at the cell membrane and cytoplasm. Statistical analysis showed a non-significant relationship between survival and transporter expression and in vitro drug sensitivity. In conclusion, the nucleoside transporters hENT1 and hCNT1 are broadly expressed in pediatric acute myeloid leukemia at diagnosis."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.org/dc/terms/identifier | "doi:10.1080/15257770.2020.1746803"xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Jansen G."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Peters G.J."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Broekhuizen R."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Pastor-Anglada M."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Cloos J."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Hubeek I."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Jaramillo A.C."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/author | "Kaspers G.J.L."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/name | "Nucleosides Nucleotides Nucleic Acids"xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/pages | "1379-1388"xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/title | "Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/32312148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32312148 |
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