| http://purl.uniprot.org/citations/32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32312382 | http://www.w3.org/2000/01/rdf-schema#comment | "Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include vascular rarefaction and geographic atrophy. By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, we show that targeting signaling downstream of VEGFR2 pY949 limits vascular permeability in retinopathy induced by high oxygen or by laser-wounding. Although suppressed permeability is accompanied by reduced pathological neoangiogenesis in oxygen-induced retinopathy, similarly sized lesions leak less in mutant mice, separating regulation of permeability from angiogenesis. Strikingly, vascular endothelial (VE)-cadherin phosphorylation at the Y685, but not Y658, residue is reduced when VEGFR2 pY949 signaling is impaired. These findings support a mechanism whereby VE-cadherin Y685 phosphorylation is selectively associated with excessive vascular leakage. Therapeutically, targeting VEGFR2-regulated VE-cadherin phosphorylation could suppress edema while leaving other VEGFR2-dependent functions intact."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.54056"xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Gordon E."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Vestweber D."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Dejana E."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Claesson-Welsh L."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Kvanta A."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Smith R.O."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Andre H."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/author | "Ninchoji T."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/pages | "e54056"xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/title | "Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin."xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32312382 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32312382 |
| http://purl.uniprot.org/citations/32312382 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32312382 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQW9-mappedCitation-32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32312382 |
| http://purl.uniprot.org/uniprot/#_P35918-mappedCitation-32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32312382 |
| http://purl.uniprot.org/uniprot/#_Q3UQZ6-mappedCitation-32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32312382 |
| http://purl.uniprot.org/uniprot/#_P55284-mappedCitation-32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32312382 |
| http://purl.uniprot.org/uniprot/#_Q3TJ23-mappedCitation-32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32312382 |
| http://purl.uniprot.org/uniprot/#_Q3TA00-mappedCitation-32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32312382 |
| http://purl.uniprot.org/uniprot/#_Q5D0E4-mappedCitation-32312382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32312382 |