| http://purl.uniprot.org/citations/32323921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32323921 | http://www.w3.org/2000/01/rdf-schema#comment | "Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential biomarkers for risk stratification, by utilizing a gene co-expression network of transcriptomics data in addition to laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation of oxidative phosphorylation (OXPHOS) in PCa on the transcriptomic level and up-regulation of the TCA cycle/OXPHOS on the proteomic level, which is inversely correlated to STAT3 expression. We hereby identify gene expression of pyruvate dehydrogenase kinase 4 (PDK4), a key regulator of the TCA cycle, as a promising independent prognostic marker in PCa. PDK4 predicts disease recurrence independent of diagnostic risk factors such as grading, staging, and PSA level. Therefore, low PDK4 is a promising marker for PCa with dismal prognosis."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.org/dc/terms/identifier | "doi:10.15252/msb.20199247"xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Haitel A."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Hofer A."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Aberger F."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Kenner L."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Schlederer M."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Pecoraro M."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Bolis M."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Brehme M."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Weiss T."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Hantusch B."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Mohr T."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Koellensperger G."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Pollheimer J."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Theurillat J.P."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Jager A."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Lagger S."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Hogler S."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Oberhuber G."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Egger G."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Haslinger P."xsd:string |
| http://purl.uniprot.org/citations/32323921 | http://purl.uniprot.org/core/author | "Wadsak W."xsd:string |