| http://purl.uniprot.org/citations/32327662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32327662 | http://www.w3.org/2000/01/rdf-schema#comment | "Plexins are receptors for semaphorins that transduce signals for regulating neuronal development and other processes. Plexins are single-pass transmembrane proteins with multiple domains in both the extracellular and intracellular regions. Semaphorin activates plexin by binding to its extracellular N-terminal Sema domain, inducing the active dimer of the plexin intracellular region. The mechanism underlying this activation process of plexin is incompletely understood. We present cryo-electron microscopic structure of full-length human PlexinC1 in complex with the viral semaphorin mimic A39R. The structure shows that A39R induces a specific dimer of PlexinC1 where the membrane-proximal domains from the two PlexinC1 protomers are placed close to each other, poised to promote the active dimer of the intracellular region. This configuration is imposed by a distinct conformation of the PlexinC1 extracellular region, stabilized by inter-domain interactions among the Sema and membrane-proximal domains. Our mutational analyses support the critical role of this conformation in PlexinC1 activation."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-15862-0"xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/author | "Tian H."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/author | "Shang G."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/author | "Bai X.C."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/author | "Kuo Y.C."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/author | "Uchikawa E."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/pages | "1953"xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/title | "Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation."xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32327662 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32327662 |
| http://purl.uniprot.org/citations/32327662 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32327662 |
| http://purl.uniprot.org/uniprot/#_O60486-mappedCitation-32327662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32327662 |
| http://purl.uniprot.org/uniprot/#_Q8JL80-mappedCitation-32327662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32327662 |
| http://purl.uniprot.org/uniprot/Q8JL80 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32327662 |
| http://purl.uniprot.org/uniprot/O60486 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32327662 |