| http://purl.uniprot.org/citations/32328625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32328625 | http://www.w3.org/2000/01/rdf-schema#comment | "Accurate chromosome segregation depends on the proper attachment of kinetochores to spindle microtubules before anaphase onset. The Ipl1/Aurora B kinase corrects improper attachments by phosphorylating kinetochore components and so releasing aberrant kinetochore-microtubule interactions. The localization of Ipl1 to kinetochores in budding yeast depends upon multiple pathways, including the Bub1-Bub3 pathway. We show here that in meiosis, Bub3 is crucial for correction of attachment errors. Depletion of Bub3 results in reduced levels of kinetochore-localized Ipl1 and concomitant massive chromosome missegregation caused by incorrect chromosome-spindle attachments. Depletion of Bub3 also results in shorter metaphase I and metaphase II due to premature localization of protein phosphatase 1 (PP1) to kinetochores, which antagonizes Ipl1-mediated phosphorylation. We propose a new role for the Bub1-Bub3 pathway in maintaining the balance between kinetochore localization of Ipl1 and PP1, a balance that is essential for accurate meiotic chromosome segregation and timely anaphase onset."xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201909136"xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/author | "Lacefield S."xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/author | "Cairo G."xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/author | "MacKenzie A.M."xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/pages | "e201909136"xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/title | "Differential requirement for Bub1 and Bub3 in regulation of meiotic versus mitotic chromosome segregation."xsd:string |
| http://purl.uniprot.org/citations/32328625 | http://purl.uniprot.org/core/volume | "219"xsd:string |
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