| http://purl.uniprot.org/citations/32331438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32331438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32331438 | http://www.w3.org/2000/01/rdf-schema#comment | "Russia has one of the largest and fastest growing HIV epidemics. However, epidemiological data are scarce. Sub-subtype A6 is most prevalent in Russia but its identification is challenging. We analysed protease/reverse transcriptase-, integrase-sequences, and epidemiological data from 303 patients to develop a methodology for the systematisation of A6 identification and to describe the HIV epidemiology in the Russian Southern Federal District. Drug consumption (32.0%) and heterosexual contact (27.1%) were the major reported transmission risks. This study successfully established the settings for systematic identification of A6 samples. Low frequency of subtype B (3.3%) and large prevalence of sub-subtype A6 (69.6%) and subtype G (23.4%) were detected. Transmitted PI-(8.8%) and NRTI-resistance (6.4%) were detected in therapy-naive patients. In therapy-experienced patients, 17.3% of the isolates showed resistance to PIs, 50.0% to NRTI, 39.2% to NNRTIs, and 9.5% to INSTIs. Multiresistance was identified in 52 isolates, 40 corresponding to two-class resistance and seven to three-class resistance. Two resistance-associated-mutations significantly associated to sub-subtype A6 samples: A62VRT and G190SRT. This study establishes the conditions for a systematic annotation of sub-subtype A6 to normalise epidemiological studies. Accurate knowledge on South Russian epidemiology will allow for the development of efficient regional frameworks for HIV-1 infection management."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.org/dc/terms/identifier | "doi:10.3390/v12040475"xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Sonnerborg A."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Sonnerborg A."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Bobkova M."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Bobkova M."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Kaiser R."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Kaiser R."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Heger E."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Heger E."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Sierra S."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Sierra S."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Bohm M."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Bohm M."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Schlosser M."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Schlosser M."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Hutt K."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Hutt K."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Di Cristanziano V."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Di Cristanziano V."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Shemshura A."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Shemshura A."xsd:string |
| http://purl.uniprot.org/citations/32331438 | http://purl.uniprot.org/core/author | "Zazzi M."xsd:string |