| http://purl.uniprot.org/citations/32332729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32332729 | http://www.w3.org/2000/01/rdf-schema#comment | "The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to globally map the mRNA targets of the RBP MSI2 in mammalian adult normal and malignant stem cells. We reveal a unique MUSASHI-2 (MSI2) mRNA binding network in hematopoietic stem cells that changes during transition to multipotent progenitors. Additionally, we discover a significant increase in RNA binding activity of MSI2 in leukemic stem cells compared with normal hematopoietic stem and progenitor cells, resulting in selective regulation of MSI2's oncogenic targets. This provides a basis for MSI2 increased dependency in leukemia cells compared to normal cells. Moreover, our study provides a way to measure RBP function in rare cells and suggests that RBPs can achieve differential binding activity during cell state transition independent of gene expression."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-15814-8"xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Patel P."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Park S.M."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Prieto C."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Vu L.P."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Chin C.R."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Kharas M.G."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Chu K.L."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Schurer A."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Nguyen D.T.T."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Leslie C.S."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Savino A.M."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Gourkanti S."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Barin E."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/author | "Choo Z.N."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/pages | "2026"xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/title | "HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells."xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32332729 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32332729 |