| http://purl.uniprot.org/citations/32344037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32344037 | http://www.w3.org/2000/01/rdf-schema#comment | "Stress is a common trigger of stress-related illnesses, such as anxiety, phobias, depression and post-traumatic stress disorder (PTSD). Various animal models successfully reproduce core behaviors of these clinical conditions. Here, we develop a novel zebrafish model of stress (potentially relevant to human stress-related disorders), based on delayed persistent behavioral, endocrine and genomic responses to an acute severe 'combined' stressor. Specifically, one week after adult zebrafish were exposed to a complex combined 90-min stress, we assessed their behaviors in the novel tank and the light-dark box tests, as well as whole-body cortisol and brain gene expression, focusing on genomic biomarkers of microglia, astrocytes, neuroinflammation, apoptosis and epigenetic modulation. Overall, stressed fish displayed persistent anxiety-like behavior, elevated whole-body cortisol, as well as upregulated brain mRNA expression of genes encoding the glucocorticoid receptor, neurotrophin BDNF and its receptors (TrkB and P75), CD11b (a general microglial biomarker), COX-2 (an M1-microglial biomarker), CD206 (an M2-microglial biomarker), GFAP (a general astrocytal biomarker), C3 (an A1-astrocytal biomarker), S100α10 (an A2-astrocytal biomarker), as well as pro-inflammatory cytokines IL-6, IL-1β, IFN-γ and TNF-α. Stress exposure also persistently upregulated the brain expression of several key apoptotic (Bax, Caspase-3, Bcl-2) and epigenetic genes (DNMT3a, DNMT3b, HAT1, HDAC4) in these fish. Collectively, the present model not only successfully recapitulates lasting behavioral and endocrine symptoms of clinical stress-related disorders, but also implicates changes in neuroglia, neuroinflammation, apoptosis and epigenetic modulation in long-term effects of stress pathogenesis in vivo."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbr.2020.112644"xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Hu G."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Song C."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Yan D."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Demin K.A."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Kalueff A.V."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Strekalova T."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Alpyshov E.T."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "Serikuly N."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/author | "de Abreu M.S."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/name | "Behav Brain Res"xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/pages | "112644"xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/title | "Delayed behavioral and genomic responses to acute combined stress in zebrafish, potentially relevant to PTSD and other stress-related disorders: Focus on neuroglia, neuroinflammation, apoptosis and epigenetic modulation."xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://purl.uniprot.org/core/volume | "389"xsd:string |
| http://purl.uniprot.org/citations/32344037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32344037 |
| http://purl.uniprot.org/citations/32344037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32344037 |
| http://purl.uniprot.org/uniprot/#_F1QSJ9-mappedCitation-32344037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32344037 |
| http://purl.uniprot.org/uniprot/#_Q5XJJ5-mappedCitation-32344037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32344037 |