| http://purl.uniprot.org/citations/32350114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32350114 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32350114 | http://www.w3.org/2000/01/rdf-schema#comment | "Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates host defense responses and development. ZBP1 activation triggers inflammation and pyroptosis, necroptosis, and apoptosis (PANoptosis) by activating receptor-interacting Ser/Thr kinase 3 (RIPK3), caspase-8, and the NLRP3 inflammasome. ZBP1 is unique among innate immune sensors because of its N-terminal Zα1 and Zα2 domains, which bind to nucleic acids in the Z-conformation. However, the specific role of these Zα domains in orchestrating ZBP1 activation and subsequent inflammation and cell death is not clear. Here we generated Zbp1ΔZα2/ΔZα2 mice that express ZBP1 lacking the Zα2 domain and demonstrate that this domain is critical for influenza A virus-induced PANoptosis and underlies perinatal lethality in mice in which the RIP homotypic interaction motif domain of RIPK1 has been mutated (Ripk1mRHIM/mRHIM). Deletion of the Zα2 domain in ZBP1 abolished influenza A virus-induced PANoptosis and NLRP3 inflammasome activation. Furthermore, deletion of the Zα2 domain of ZBP1 was sufficient to rescue Ripk1mRHIM/mRHIM mice from perinatal lethality caused by ZBP1-driven cell death and inflammation. Our findings identify the essential role of the Zα2 domain of ZBP1 in several physiological functions and establish a link between Z-RNA sensing via the Zα2 domain and promotion of influenza-induced PANoptosis and perinatal lethality."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra120.013752"xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra120.013752"xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Kesavardhana S."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Kesavardhana S."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Malireddi R.K.S."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Malireddi R.K.S."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Pruett-Miller S.M."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Pruett-Miller S.M."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Burton A.R."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Burton A.R."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Porter S.N."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/author | "Porter S.N."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/pages | "8325-8330"xsd:string |
| http://purl.uniprot.org/citations/32350114 | http://purl.uniprot.org/core/pages | "8325-8330"xsd:string |