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| http://purl.uniprot.org/citations/32359537 | http://www.w3.org/2000/01/rdf-schema#comment | "The fruit fly, Drosophila melanogaster, is predominantly found in overripe, rotten, fermenting, or decaying fruits and is constantly exposed to chemical stressors such as acetic acid, ethanol, and 2-phenylethanol. D. melanogaster has been employed as a model system for studying the molecular bases of various types of chemical-induced tolerance. Expression profiling using Illumina sequencing has been performed for identifying changes in gene expression that may be associated with evolutionary adaptation to exposure of acetic acid, ethanol, and 2-phenylethanol. We identified a total of 457 differentially expressed genes that may affect sensitivity or tolerance to three chemicals in the chemical treatment group as opposed to the control group. Gene-set enrichment analysis revealed that the genes involved in metabolism, multicellular organism reproduction, olfaction, regulation of signal transduction, and stress tolerance were over-represented in response to chemical exposure. Furthermore, we also detected a coordinated upregulation of genes in the Toll- and Imd-signaling pathways after the chemical exposure. Quantitative reverse transcription PCR analysis revealed that the expression levels of nine genes within the set of genes identified by RNA sequencing were up- or downregulated owing to chemical exposure. Taken together, our data suggest that such differentially expressed genes are coordinately affected by chemical exposure. Transcriptional analyses after exposure of D. melanogaster with three chemicals provide unique insights into subsequent functional studies on the mechanisms underlying the evolutionary adaptation of insect species to environmental chemical stressors."xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pestbp.2020.02.018"xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/author | "Pittendrigh B.R."xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/author | "Seong K.M."xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/name | "Pestic Biochem Physiol"xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/pages | "104552"xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/title | "Identification of transcriptional responsive genes to acetic acid, ethanol, and 2-phenylethanol exposure in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/32359537 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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