| http://purl.uniprot.org/citations/32372324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32372324 | http://www.w3.org/2000/01/rdf-schema#comment | "Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10522-020-09881-z"xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/author | "Lu C."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/author | "Shao X."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/name | "Biogerontology"xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/pages | "637-652"xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/title | "Functional alterations and transcriptomic changes during zebrafish cardiac aging."xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/32372324 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32372324 |
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