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http://purl.uniprot.org/citations/32376910http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32376910http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32376910http://www.w3.org/2000/01/rdf-schema#comment"The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 Å, with local resolutions reaching 4.5 Å. Improved resolutions allow identification and placement of secondary structural elements in the majority of the CR components. The two Y complexes in each CR subunit interact with each other and associate with those from flanking subunits, forming a circular scaffold. Within each CR subunit, the Nup358-containing region wraps around the stems of both Y complexes, likely stabilizing the scaffold. Nup205 connects the short arms of the two Y complexes and associates with the stem of a neighboring Y complex. The Nup214-containing region uses an extended coiled-coil to link Nup85 of the two Y complexes and protrudes into the axial pore of the NPC. These previously uncharacterized structural features reveal insights into NPC assembly."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.org/dc/terms/identifier"doi:10.1038/s41422-020-0319-4"xsd:string
http://purl.uniprot.org/citations/32376910http://purl.org/dc/terms/identifier"doi:10.1038/s41422-020-0319-4"xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Huang G."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Huang G."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Liu M."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Liu M."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Shi Y."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Shi Y."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Wang Q."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Wang Q."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zhu X."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zhu X."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Tao Q."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Tao Q."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zhou Q."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zhou Q."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zeng C."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Zeng C."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Lei J."xsd:string
http://purl.uniprot.org/citations/32376910http://purl.uniprot.org/core/author"Lei J."xsd:string