| http://purl.uniprot.org/citations/32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32379419 | http://www.w3.org/2000/01/rdf-schema#comment | "Iron metabolism imbalance plays a key role in the neurodegeneration of Parkinson's disease (PD), thus iron homeostasis should be tightly controlled by iron transporters. α-Synuclein (α-Syn) serves as a ferrireductase and iron-binding protein, which is supposed to be linked with iron metabolism, but little is known about how α-Syn affects iron homeostasis in PD. Our previous findings that up-regulation of divalent metal transporter 1 (DMT1) accounted for the nigral iron accumulation in PD raised the question whether α-Syn disturbed iron homeostasis by modulating DMT1 expression. Using α-Syn overexpressed SH-SY5Y cells and mutant human A53T α-Syn transgenic mice, we found that α-Syn could up-regulate DMT1 protein levels, followed by enhanced ferrous iron influx and subsequent aggravated oxidative stress injury. Mechanistic studies identified that α-Syn-induced p38 mitogen-activated protein kinase (MAPK) activation phosphorylated parkin at Ser131, which inactivated parkin's E3 ubiquitin ligase activity and further reduced DMT1 ubiquitylation level. Our findings revealed that α-Syn affected brain iron homeostasis through modulating DMT1 protein stability and altering cellular iron uptake, which might provide direct evidence for the involvement of α-Syn in iron metabolism dysfunction and provide insight into PD-associated nigral iron deposition."xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.org/dc/terms/identifier | "doi:10.1021/acschemneuro.0c00196"xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/author | "Bi M."xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/author | "Jiao Q."xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/name | "ACS Chem Neurosci"xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/pages | "1682-1691"xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/title | "alpha-Synuclein Regulates Iron Homeostasis via Preventing Parkin-Mediated DMT1 Ubiquitylation in Parkinson's Disease Models."xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32379419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32379419 |
| http://purl.uniprot.org/citations/32379419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32379419 |
| http://purl.uniprot.org/uniprot/#_A0A0A1EL53-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_D3JZW5-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_D3K2X1-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_D3K2X2-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z446-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z447-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_A0A0A1E835-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_A0A0H3W5I8-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_A0A0H3W5U4-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |
| http://purl.uniprot.org/uniprot/#_A0A1W5XGD7-mappedCitation-32379419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32379419 |