| http://purl.uniprot.org/citations/32386193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32386193 | http://www.w3.org/2000/01/rdf-schema#comment | "Myocardial hypertrophy is a major pathological and physiological process during heart failure. Glucagon-like peptide 1 (GLP-1) is a glucagon incretin hormone released from the gut endocrine L-cells that has protective effects on various cardiovascular diseases, including hypertension, atherosclerosis, and myocardial hypertrophy. However, the protective mechanisms of GLP-1 in myocardial hypertrophy remain unclear. Here, we showed that the GLP-1 agonist liraglutide and dipeptidyl peptidase 4 inhibitor alogliptin decreased heart weight and cardiac muscle cell volume in spontaneously hypertensive rats (SHR). In H9C2 cell hypertensive models induced by angiotensin II, GLP-1 treatment reduced myocardial cell volume, inhibited the expressions of atrial natriuretic peptide, brain/B-type natriuretic peptide, β-myosin heavy chain, RhoA, and ROCK2, and decreased MLC and MYPT1 phosphorylation. When H9C2 cells were treated with H89, a PKA inhibitor, the inhibitory effect of GLP-1 disappeared, while the inhibitory role was enhanced under the treatment of Y-27632, a ROCK2 inhibitor. These results suggested that GLP-1 might reverse myocardial hypertrophy through the PKA/RhoA/ROCK2 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.org/dc/terms/identifier | "doi:10.1093/abbs/gmaa038"xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/author | "Xiong Q."xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/author | "Fan S."xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/name | "Acta Biochim Biophys Sin (Shanghai)"xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/pages | "612-619"xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/title | "Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling."xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/32386193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32386193 |
| http://purl.uniprot.org/citations/32386193 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32386193 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K5N6-mappedCitation-32386193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/#_A6HAT7-mappedCitation-32386193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/#_A6HLV7-mappedCitation-32386193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/#_G3V6P5-mappedCitation-32386193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/#_P06883-mappedCitation-32386193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/#_Q62868-mappedCitation-32386193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/Q62868 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/P06883 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/A6HAT7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32386193 |
| http://purl.uniprot.org/uniprot/A0A0G2K5N6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32386193 |