| http://purl.uniprot.org/citations/32390003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32390003 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteosarcoma (OS) is the most common primary bone cancer and ranks amongst the leading causes of cancer mortality in young adults. Jun activation domain-binding protein 1 (JAB1) is overexpressed in many cancers and has recently emerged as a novel target for cancer treatment. However, the role of JAB1 in osteosarcoma was virtually unknown. In this study, we demonstrate that JAB1-knockdown in malignant osteosarcoma cell lines significantly reduced their oncogenic properties, including proliferation, colony formation, and motility. We also performed RNA-sequencing analysis in JAB1-knockdown OS cells and identified 4110 genes that are significantly differentially expressed. This demonstrated for the first time that JAB1 regulates a large and specific transcriptome in cancer. We also found that JAB1 is overexpressed in human OS and correlates with a poor prognosis. Moreover, we generated a novel mouse model that overexpresses Jab1 specifically in osteoblasts upon a TP53 heterozygous sensitizing background. Interestingly, by 13 months of age, a significant proportion of these mice spontaneously developed conventional OS. Finally, we demonstrate that a novel, highly specific small molecule inhibitor of JAB1, CSN5i-3, reduces osteosarcoma cell viability, and has specific effects on the ubiquitin-proteasome system in OS. Thus, we show for the first time that the overexpression of JAB1 in vivo can result in accelerated spontaneous tumor formation in a p53-dependent manner. In summary, JAB1 might be a unique target for the treatment of osteosarcoma and other cancers."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41388-020-1320-6"xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Zhou G."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Lee B."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Elliott R."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Chan R."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Danielpour D."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Miron A."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Greenfield E.M."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Samsa W.E."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Bashur L.A."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/author | "Mamidi M.K."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/pages | "4581-4591"xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/title | "The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo."xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/32390003 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32390003 |
| http://purl.uniprot.org/citations/32390003 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32390003 |
| http://purl.uniprot.org/uniprot/#_A0A024R7W9-mappedCitation-32390003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32390003 |
| http://purl.uniprot.org/uniprot/#_Q59GH5-mappedCitation-32390003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32390003 |
| http://purl.uniprot.org/uniprot/#_Q92905-mappedCitation-32390003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32390003 |
| http://purl.uniprot.org/uniprot/Q92905 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32390003 |