| http://purl.uniprot.org/citations/32404872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32404872 | http://www.w3.org/2000/01/rdf-schema#comment | "Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. Here we show that BAF60a, a subunit of the SWI/SNF chromatin-remodeling complexes, serves an indispensable role in cold-induced thermogenesis in brown fat. BAF60a maintains chromatin accessibility at PPARγ and EBF2 binding sites for key thermogenic genes. Surprisingly, fat-specific BAF60a inactivation triggers more pronounced cold-induced browning of inguinal white adipose tissue that is linked to induction of MC2R, a receptor for the pituitary hormone ACTH. Elevated MC2R expression sensitizes adipocytes and BAF60a-deficient adipose tissue to thermogenic activation in response to ACTH stimulation. These observations reveal an unexpected dichotomous role of BAF60a-mediated chromatin remodeling in transcriptional control of brown and beige gene programs and illustrate a pituitary-adipose signaling axis in the control of thermogenesis."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-16148-1"xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Parker S.C.J."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Yu Q."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Xiong J."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Lin J.D."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Zhao X.Y."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Mi L."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Orchard P."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/author | "Meng Z.X."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/pages | "2379"xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/title | "BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning."xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32404872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32404872 |
| http://purl.uniprot.org/citations/32404872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32404872 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHB7-mappedCitation-32404872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32404872 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI06-mappedCitation-32404872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32404872 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI28-mappedCitation-32404872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32404872 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VKP3-mappedCitation-32404872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32404872 |