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| http://purl.uniprot.org/citations/32413698 | http://www.w3.org/2000/01/rdf-schema#comment | "Excitatory amino acid transporter-2 (EAAT-2) protein localized in the membrane of glial cells are responsible for the clearance of glutamate in synapse and it plays a key role among the five glutamate transporters (EAATs) in regulating synaptic transmission and preventing excitotoxicity in neurons. EAAT-2 dysfunction has been associated with the neuropathology of Alzheimer's disease (AD). Impairment of EAAT-2 transporter function results excess accumulation of glutamate in synaptic cleft that acts on post-synaptic glutaminergic receptors excessively resulting in influx of Na+ and Ca2+ ions into the neurons. This triggers excitotoxicity in post-synaptic neurons by activating apoptotic or necrotic pathways causing neurodegeneration in AD. The compounds that increase the EAAT-2 activity may have therapeutic potential for neuroprotection in AD. The positive allosteric site activation of EAAT-2 represents a promising entry point for the identification of novel pharmacological compounds for the management of neurodegenerative conditions involving glutamate-mediated excitotoxicity. We hypothesize, therefore, that the positive allosteric activators may enhance glutamate clearance from the synaptic cleft by promoting orthosteric binding of glutamate ligand in EAAT-2 transporter protein and attenuate the excitotoxicity in neurons and prevent the disease progression of AD."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mehy.2020.109794"xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/author | "Manisha C."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/author | "Selvaraj A."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/author | "Justin A."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/author | "Clement J.P."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/author | "Jubie S."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/author | "Moola Joghee N."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/author | "Moola Joghee Nanjan C."xsd:string |
| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
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| http://purl.uniprot.org/citations/32413698 | http://purl.uniprot.org/core/title | "Positive allosteric activation of glial EAAT-2 transporter protein: A novel strategy for Alzheimer's disease."xsd:string |
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