| http://purl.uniprot.org/citations/32420597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32420597 | http://www.w3.org/2000/01/rdf-schema#comment | "Prader-Willi syndrome (PWS) is caused by deficient expression of the paternal copy of several contiguous genes on chromosome 15q11-q13 and affects multiple organ systems in the body, including the nervous system. Feeding and suckling deficits in infants with PWS are replaced with excessive feeding and obesity in childhood through adulthood. Clinical trials using intranasal oxytocin (OXT) show promise to improve feeding deficits in infants with PWS. The mechanism and location of action of exogenous OXT are unknown. We have recently shown in neonatal mice that OXT receptors (OXTR) are present in several regions of the face with direct roles in feeding. Here we show that the trigeminal ganglion, which provides sensory innervation to the face, is a rich source of Oxtr and a site of cellular co-expression with PWS gene transcripts. We also quantified OXTR ligand binding in mice deficient in Magel2, a PWS gene, within the trigeminal ganglion and regions that are anatomically relevant to feeding behavior and innervated by the trigeminal ganglion including the lateral periodontium, rostral periodontium, tongue, olfactory epithelium, whisker pads and brainstem. We found that peripheral OXTR ligand binding in the head is mostly intact in Magel2-deficient mice, although it is reduced in the lateral periodontium (gums) of neonatal Magel2-deficient mice compared to wild-type controls. These data suggest that OXT via orofacial OXTR may play a peripheral role to modulate sensory-motor reflexes necessary for suckling and may be part of the mechanism by which intranasal OXT shows promise for therapeutic benefit in PWS."xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddaa094"xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/author | "Muscatelli F."xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/author | "Vaidyanathan R."xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/author | "Schaller F."xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/author | "Hammock E.A.D."xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/pages | "2065-2075"xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/title | "Colocalization of Oxtr with Prader-Willi syndrome transcripts in the trigeminal ganglion of neonatal mice."xsd:string |
| http://purl.uniprot.org/citations/32420597 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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