| http://purl.uniprot.org/citations/32423810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32423810 | http://www.w3.org/2000/01/rdf-schema#comment | "Septic shock induced by lipopolysaccharide (LPS) is characterized by serious systemic inflammatory response and robust production of pro-inflammatory cytokines from activated macrophages. Damage-associated molecular patterns (DAMPs) secreted by activated macrophages are key contributors to septic shock. However, the current knowledge on those DAMPs that promote inflammatory response under LPS-induced septic shock remains poorly understood. Here, we report that Peroxiredoxin 1 (Prdx1) plays a detrimental role in LPS-induced septic shock. Intraperitoneal injection of LPS elicited a progressive course of septic shock in mice, which was characterized by significant lethality along with robust production of cytokines (IL-1β, IL-6 and TNF-α). Removal of Prdx1 strongly protected mice from LPS-induced death, and decreased IL-1β, IL-6 and TNF-α productions. Additionally, primary macrophages deficient in Prdx1 are less able to produce much more IL-1β, IL-6 and TNF-α. Collectively, we provide a demonstration for Prdx1 contributing to LPS-induced septic shock likely via promoting inflammation."xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2020.04.149"xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/author | "Tao L."xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/author | "Peng Z."xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/pages | "861-865"xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/title | "Peroxiredoxin-1 aggravates lipopolysaccharide-induced septic shock via promoting inflammation."xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://purl.uniprot.org/core/volume | "527"xsd:string |
| http://purl.uniprot.org/citations/32423810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32423810 |
| http://purl.uniprot.org/citations/32423810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32423810 |
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| http://purl.uniprot.org/uniprot/#_B1AXW5-mappedCitation-32423810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32423810 |
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| http://purl.uniprot.org/uniprot/#_P35700-mappedCitation-32423810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32423810 |
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| http://purl.uniprot.org/uniprot/B1AXW6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32423810 |
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| http://purl.uniprot.org/uniprot/B1AXW4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32423810 |