| http://purl.uniprot.org/citations/32426479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32426479 | http://www.w3.org/2000/01/rdf-schema#comment | "The therapeutic effects of l-3,4-dihydroxyphenylalanine (l-DOPA) in patients with Parkinson's disease (PD) severely diminishes with the onset of abnormal involuntary movement, l-DOPA-induced dyskinesia (LID). However, the molecular mechanisms that promote LID remain unclear. Here, we demonstrated that RasGRP1 [(guanine nucleotide exchange factor (GEF)] controls the development of LID. l-DOPA treatment rapidly up-regulated RasGRP1 in the striatum of mouse and macaque model of PD. The lack of RasGRP1 in mice (RasGRP1-/- ) dramatically diminished LID without interfering with the therapeutic effects of l-DOPA. Besides acting as a GEF for Ras homolog enriched in the brain (Rheb), the activator of the mammalian target of rapamycin kinase (mTOR), RasGRP1 promotes l-DOPA-induced extracellular signal-regulated kinase (ERK) and the mTOR signaling in the striatum. High-resolution tandem mass spectrometry analysis revealed multiple RasGRP1 downstream targets linked to LID vulnerability. Collectively, the study demonstrated that RasGRP1 is a critical striatal regulator of LID."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aaz7001"xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Subramaniam S."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Tsaprailis G."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Usiello A."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "De Rosa A."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Nuzzo T."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Eshraghi M."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Bezard E."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Shahani N."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Rivera O."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Crynen G."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Thiolat M.L."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Swarnkar S."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Scharager-Tapia C."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Ramirez-Jarquin U.N."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/author | "Galli N."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/pages | "eaaz7001"xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/title | "RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/32426479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32426479 |