| http://purl.uniprot.org/citations/32427863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32427863 | http://www.w3.org/2000/01/rdf-schema#comment | "Neovascularization and vascular remodeling are functionally important for brain repair after stroke. We show that neutrophils accumulate in the peri-infarct cortex during all stages of ischemic stroke. Neutrophils producing intravascular and intraparenchymal neutrophil extracellular traps (NETs) peak at 3-5 days. Neutrophil depletion reduces blood-brain barrier (BBB) breakdown and enhances neovascularization at 14 days. Peptidylarginine deiminase 4 (PAD4), an enzyme essential for NET formation, is upregulated in peri-ischemic brains. Overexpression of PAD4 induces an increase in NET formation that is accompanied by reduced neovascularization and increased BBB damage. Disruption of NETs by DNase 1 and inhibition of NET formation by genetic ablation or pharmacologic inhibition of PAD increases neovascularization and vascular repair and improves functional recovery. Furthermore, PAD inhibition reduces stroke-induced STING-mediated production of IFN-β, and STING knockdown and IFN receptor-neutralizing antibody treatment reduces BBB breakdown and increases vascular plasticity. Collectively, our results indicate that NET release impairs vascular remodeling during stroke recovery."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-16191-y"xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Kang L."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Fan W."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Bai X."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Zhao B.Q."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/author | "Shi M.J."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/pages | "2488"xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/title | "Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke."xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32427863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32427863 |
| http://purl.uniprot.org/citations/32427863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32427863 |
| http://purl.uniprot.org/uniprot/#_Q9Z183-mappedCitation-32427863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32427863 |